Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]- 2H-1,2,4-triazole-3-thiones

Namratha, B and Gaonkar, Santosh L (2014) Synthesis and Antimicrobial Screening of Novel 4-Substituted Phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl]- 2H-1,2,4-triazole-3-thiones. International Scholarly Research Notices.

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Abstract

The paper describes a convenient method for the preparation of 4-substituted phenyl-5-[1-(4-fluorophenyl)-1,3-dihydroisobenzofuran- 5-yl]-2H-1,2,4-triazole-3-thiones. The structures of the synthesized compounds are established by the results of LCMS, 1HNMR, 13C NMR, and IR and elemental analyses.The mercaptotriazoles are indicated to be in thione form by 1HNMR spectra. All the synthesized compounds have been screened for antibacterial and antifungal activities. Compounds 12d and 12h exhibit encouraging results, while the remaining compounds show moderate activities. On the basis of spectral studies, formation of 2- amino-1,3,4-thiadiazoles from the isobenzofuran acyl thiosemicarbazides 11(a–h) is ruled out.

Item Type: Article
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 22 Jun 2015 06:42
Last Modified: 22 Jun 2015 06:42
URI: http://eprints.manipal.edu/id/eprint/143110

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