Microwave-Assisted and Conventional Synthesis of Benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines: A Comparative Study

Gaonkar, Santosh L and Ahn, Chuljin and Princia, . and Shetty, Nitinkumar S (2014) Microwave-Assisted and Conventional Synthesis of Benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines: A Comparative Study. Journal of the Korean Chemical Society, 58 (4). pp. 388-392.

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Abstract

Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4]triazolo[4,3-c] pyrimidines (5a−c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.

Item Type: Article
Uncontrolled Keywords: Conventional method, Microwave irradiation, Thienopyrimidine, Triazolothienopyrimidine
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 22 Jun 2015 06:47
Last Modified: 22 Jun 2015 06:47
URI: http://eprints.manipal.edu/id/eprint/143113

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