A Facile Microwave-Assisted Synthesis of Novel Thienopyrimidines and Triazolothienopyrimidines and their Antimicrobial Activities

Shetty, Nitinkumar S (2014) A Facile Microwave-Assisted Synthesis of Novel Thienopyrimidines and Triazolothienopyrimidines and their Antimicrobial Activities. International Journal of Advances in Chemical Engineering and Biological Sciences, 1 (1). pp. 80-84. ISSN 2349-1507

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Abstract

Thienopyrimidines (2, 3, 4) and triazolo- thienopyrimidines (5a-c) were prepared from the precursor 2-amino-5, 5-dimethyl-7-oxo-4, 5, 6, 7-tetrahydro-1-benzothiophene-3-carbonitrile (1) by employing the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue (1) was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses is more efficient than the classical heating method. The structures of all the compounds were ascertained by spectral and analytical data. The compounds have showed promising antibacterial and antifungal activities

Item Type: Article
Uncontrolled Keywords: Antibacterial activity, Antifungal activity, Microwave irradiation, Thienopyrimidine, Triazolothienopyrimidine
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 18 Dec 2015 11:03
Last Modified: 18 Dec 2015 11:03
URI: http://eprints.manipal.edu/id/eprint/144871

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