In vitro anti-inflammatory activity of carmona Retusa (vahl.)

Chandrappa, C P and Govindappa, M and Kumar, Anil N V and Channabasava, R (2015) In vitro anti-inflammatory activity of carmona Retusa (vahl.). World Journal of Pharmacy and Pharmaceutical Sciences, 2 (5). pp. 3991-3997. ISSN 2278 – 4357

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Abstract

The anti-inflammatory activity of ethanol extract of stem of Carmona retusa was investigated for in-vitro anti-inflammatory activity by human red blood cell membrane stabilization method, heat induced hemolysis and proteinase inhibitory activity. The anti-inflammatory activity of Carmona retusa found maximum in human red blood cell membrane stabilization method, heat induced hemolysis and proteinase inhibitory activity as 55.72%, 56.37% and 61.75% respectively at 400μg/ml concentration. Minimum anti-inflammatory activity has shown at 50μg/ml concentration as 28.92μg/ml, 15.43μg/ml and 11.33μg/ml in the methods used. IC50 values were calculated for all the methods and found to 30.31, 19.62 and14.53μg/ml for human red blood cell membrane stabilization method, heat induced hemolysis and proteinase inhibitory activity respectively. The anti-inflammatory activity of the sample was comparable with that of the standard diclofenac. The results obtained in the present study suggest that Carmona retusa can be a potential source of antiinflammatory agents.

Item Type: Article
Uncontrolled Keywords: Carmona retusa, anti-inflammatory activity, HRBC, IC50.
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 21 Dec 2015 10:26
Last Modified: 21 Dec 2015 11:05
URI: http://eprints.manipal.edu/id/eprint/144891

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