Synthesis and antibacterial screening of few new 5-membered heterocyclic sugar hydrazones

Namratha, B and Shetty, Nitinkumar S and Gaonkar, Santosh L (2016) Synthesis and antibacterial screening of few new 5-membered heterocyclic sugar hydrazones. Asian Journal of Pharmaceutical and Clinical Research, 9 (3). pp. 141-144. ISSN 0974-2441

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Abstract

Objective: The aim of this study is to synthesize, characterize, and screen some new 5-membered heterocyclic sugar hydrazones for their antibacterial activities. Methods: A library of sugar hydrazones containing 2-benzofuryl, 2-thiophenyl, and 2-pyrrolyl motifs were synthesized. Structures of the newly synthesized compounds were deduced based on spectral data and elemental analyses. Results: Antibacterial activity was screened against Gram-positive and Gram-negative bacterial strains. Results were compared to gentamicin. Compound 6a exhibited most potent antibacterial activity against all the tested strains. Conclusion: 2-benzofuryl derivatives were observed to be good antibacterials

Item Type: Article
Uncontrolled Keywords: Benzofuran, Thiophene, Pyrrole, Antibacterial, Sugar.
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 25 May 2016 11:52
Last Modified: 25 May 2016 11:52
URI: http://eprints.manipal.edu/id/eprint/146145

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