Nano-Chitosan Particles in Anticancer Drug Delivery: An Up-to-Date Review

Kamath, Pooja R and Sunil, Dhanya (2017) Nano-Chitosan Particles in Anticancer Drug Delivery: An Up-to-Date Review. Mini-Reviews in Medicinal Chemistry, 17 (15). pp. 1457-1487. ISSN 1389-5575

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Abstract

Cancer is one of the most awful lethal diseases all over the world and the success of its current chemotherapeutic treatment strategies is limited due to several associated drawbacks. The exploration of cancer cell physiology and its microenvironment has exposed the potential of various classes of nanocarriers to deliver anticancer chemotherapeutic agents at the tumor target site. These nanocarriers must evade the immune surveillance system and achieve target selectivity. Besides, they must gain access into the interior of cancerous cells, evade endosomal entrapment and discharge the drugs in a sustained manner. Chitosan, the second naturally abundant polysaccharide is a biocompatible, biodegradable and mucoadhesive cationic polymer which has been exploited extensively in the last few years in the effective delivery of anticancer chemotherapeutics to the target tumor cells. Therapeutic agent-loaded surface modified chitosan nanoparticles are established to be more stable, permeable and bioactive.

Item Type: Article
Uncontrolled Keywords: Cancer, chemotherapy, chitosan, drug delivery, encapsulation, nanoparticles.
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 19 Sep 2017 10:33
Last Modified: 21 Sep 2017 11:11
URI: http://eprints.manipal.edu/id/eprint/149717

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