Effect of Plasma Component Transfusion on Conventional Coagulation Screening Tests

Raturi, Manish and Shastry, Shamee and Baliga, Poornima and Chakravarthy, Kalyana (2018) Effect of Plasma Component Transfusion on Conventional Coagulation Screening Tests. Asian Journal of Transfusion Science, 12 (1). pp. 57-61. ISSN 0973-6247

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BACKGROUND: Conventional coagulation screening tests such as Prothrombin time, International normalized ratio (INR) and activated partial thromboplastin time are often used to predict bleeding in various clinical situations. We aimed to observe the effect of Fresh-frozen plasma (FFP) on these parameters.METHODS: Patients’ demographics, pre- and post-transfusion coagulation parameters were noted to assess the level of correction. The magnitude of improvement in INR was determined using the formula given by Holland and Brooks. Data was analyzed using IBM SPSS Statistics 20.RESULTS: Among 2082 episodes, 4991 units of FFP were transfused at an average of 5 units per patient. Median dose of FFP administered per episode was 10 mL/kg (5.8–13.4). The mean change in INR following transfusion was 8.9% of the pre-transfusion INR and thus considered to be statistically significant.CONCLUSION: FFP transfusions as a prophylactic measure especially in patients with mildly deranged conventional coagulation screening tests without any empirical evidence of clinical bleeding needs further scrutiny. Reduction in INR following FFP transfusions was better in cohort having higher pre-transfusion INR value (> 3.0).

Item Type: Article
Uncontrolled Keywords: Blood components; Fresh frozen plasma; Hemostasis; International normalized ratio; Prophylactic transfusion therapy
Subjects: Dentistry > MCODS Manipal > Preventive and Community Dentistry
Medicine > KMC Manipal > Immunohematology and Blood Transfusion
Depositing User: KMC Library
Date Deposited: 21 Feb 2018 04:46
Last Modified: 21 Feb 2018 04:46
URI: http://eprints.manipal.edu/id/eprint/150624

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