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Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole-Linked Chalcone Derivatives

Santosh, Rangappa and Selvam, Mukunthan K. and Kanekar, Saptami U. and Nagaraja, Gundibasappa K. (2018) Synthesis, Characterization, Antibacterial and Antioxidant Studies of Some Heterocyclic Compounds from Triazole-Linked Chalcone Derivatives. ChemistrySelect, 3 (23). pp. 6338-6343. ISSN 2365-6549

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Abstract

In the current study, an efficient synthesis of new triazole-linked chalcone 3a-g scaffold was performed by multistep reaction sequence and was screened for their antibacterial activity against Pseudomonas aeruginosa, Escherchia coli, Staphylococcus aureus and Bacillus subtilis. The preliminary result revealed that 3f exhibited a promising antibacterial activity. Furthermore, 3f was modified at a, b- unsaturated carbonyl segment to isoxazoline 4a, pyrimidines 5a, 6a-b, pyrazoles 7a-c and cyanopyridine 8a. Within the modified compounds 7b (4-nitrosubstituted pyrazole) turn to be more potent against all bacterial strains. In addition compounds, 5a and 8a showed promising free radical scavenging activity.

Item Type: Article
Uncontrolled Keywords: Antibacterial · Antioxidant · DNA Binding Studies · Molecular Docking · Triazole-Chalcone · Isoxazoline- Pyrazole- Pyridine- Pyrimidines
Subjects: Engineering > MIT Manipal > Biotechnology
Depositing User: MIT Library
Date Deposited: 22 Sep 2018 04:23
Last Modified: 22 Sep 2018 04:23
URI: http://eprints.manipal.edu/id/eprint/151999

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