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Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole-Containing Triazoles as Antibacterials

Santosh, Rangappa and Selvam, Mukunthan K. and Kanekar, Saptami U. and Nagaraja, Gundibasappa K. and Kumar, Madan (2018) Design, Synthesis, DNA Binding, and Docking Studies of Thiazoles and Thiazole-Containing Triazoles as Antibacterials. ChemistrySelect, 3 (14). pp. 3892-3898. ISSN 2365-6549

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Abstract

A series of thiazoles 4a-g and thiazole clubbed triazoles 5a-f were synthesized and showed good antibacterial activity against, Pseudomonas aeruginosa, Escherchia coli, Staphylococcus aureus and Bacillus subtilis. Particularly, 4a (methyl), 5b (nitro) and 5d (fluoro) derivatives demonstrated a broad range of activity over other derivatized compounds. In addition,Computational interaction, ADMET (absorption, distribution, metabolism, and excretion - toxicity in pharmacokinetics), Lipinski’s rule and DNA binding studies of all the results stacked together indicated that 5b can be further developed as lead molecule against bacterial pathogens

Item Type: Article
Uncontrolled Keywords: Antibacterial DNA Binding studies Lipinski's rule Molecular docking Thiazoles-Triazole
Subjects: Engineering > MIT Manipal > Biotechnology
Depositing User: MIT Library
Date Deposited: 22 Sep 2018 04:26
Last Modified: 22 Sep 2018 04:26
URI: http://eprints.manipal.edu/id/eprint/152000

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