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Prognostic information from chemotherapy-associated changes in bone marrow metastasis of neuroblastoma- a case report

Singh, Varun Kumar and Vijay, Anjali S and Belurkar, Sushma V and Amber, Shiny (2019) Prognostic information from chemotherapy-associated changes in bone marrow metastasis of neuroblastoma- a case report. Indian Journal of Applied Research, 9 (6). pp. 7-9. ISSN 2249 - 555X

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Abstract

Neuroblastoma is the most common extra-cranial solid tumour in children. Bone marrow examination is a part of diagnosis and staging workup of neuroblastoma. Chemotherapy forms mainstay of treatment and post-chemotherapy histological changes are an important indicator of prognosis. A 4-year-old male child came with complaints of fever and hepatomegaly. Investigations revealed a retroperitoneal neuroblastoma. Bone marrow was involved by neuroblasts (stage 4S). Platinum-based chemotherapy was started and post-induction phase bone marrow showed differentiation of neuroblasts to ganglion cells and schwannian stroma (tumour load <5%, minimal disease). The patient was lost to follow up thereafter. The patient returned after one year with the reappearance of neuroblasts (tumour load >20%, relapse) in the bone marrow. Use of immunohistochemical markers like chromogranin and S100 are helpful to map the tumour load and identify the tumour cells when they are sparse. Persistence / reappearance of neuroblasts post-chemotherapy or increasing tumour load indicate a relapse.

Item Type: Article
Uncontrolled Keywords: Neuroblastoma; chromogranin; S100; ganglion cells; schwann cells; cisplatin.
Subjects: Medicine > MMMC Manipal > Pathology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Library
Date Deposited: 01 Jul 2019 04:35
Last Modified: 01 Jul 2019 04:35
URI: http://eprints.manipal.edu/id/eprint/154068

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