Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies

Radic, Zorica Stojanovic and Pejcˇic, Milica and Dimitrijevic´, Marina and Aleksic, Ana and Kumar, Anil N V and Salehi, Bahare and Cho, William C and Rad, Javed Sharifi (2019) Piperine-A Major Principle of Black Pepper: A Review of Its Bioactivity and Studies. Applied Sciences, 9 (4270). ISSN 1454-5101

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Abstract

Piperine is the main compound present in black pepper, and is the carrier of its specific pungent taste, which is responsible for centuries of human dietary utilization and worldwide popularity as a food ingredient. Along with the application as a food ingredient and food preservative, it isused in traditional medicine for many purposes, which has in most cases been justified by modern scientific studies on its biological effects. It has been confirmed that piperine has many bio active effects, such as anti micro bialaction, as well as many physiological effects that can contribute to general human health, including immunomodulatory, hepatoprotective, antioxidant, antimetastatic, antitumor, and many other activities. Clinical studies demonstrated remarkable antioxidant, antitumor, and drug availability-enhancing characteristics of this compound, together with immunomodulatory potential. All these facts point to the therapeuticpotentialofpiperineandtheneedtoincorporatethiscompound into general health-enhancing medical formulations, as well as into those that would be used as adjunctive therapy in order to enhance the bioavailability of various (chemo)therapeutic drugs

Item Type: Article
Uncontrolled Keywords: piperine; bioactivity; clinical studies; bioavailability of drugs
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 07 May 2020 05:59
Last Modified: 07 May 2020 05:59
URI: http://eprints.manipal.edu/id/eprint/155088

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