Synthesis, characterization and anticancer activity of 1,2,4-Triazolo [3,4-b]-1,3,4-thiadiazoles on Hep G2 cell lines

Sunil, Dhanya and Shetty, Prakash (2009) Synthesis, characterization and anticancer activity of 1,2,4-Triazolo [3,4-b]-1,3,4-thiadiazoles on Hep G2 cell lines. Der Pharma Chemica, 1 (2). pp. 19-26. ISSN 0975-413X

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Abstract

A series of 3,6-disubstituted 1,2,4–triazolo[3,4-b]-1,3,4-thiadiazoles were synthesized from 3- substituted-4-amino-5-mercapto-1,2,4-triazoles and 3-substituted 4-carboxypyrazoles. Elemental analyses, IR, 1H NMR and mass spectral data confirmed the structures of all newly synthesized compounds. Most of the newly synthesized compounds were screened for their anticancer activity in hepatic cell lines. Many of the compounds were found to be potent. The perturbations brought by the substituent can affect various parameters of the molecule like its electron density, its steric environment, its bioavailability etc. The thiadiazole with naphthyloxymethyl and fluorophenyl groups as substituents showed excellent antiproliferative effect

Item Type: Article
Uncontrolled Keywords: 1,2,4-triazoles; 4-carboxypyrazoles; 1,2,4 –triazolo [3,4-b]-1,3,4-thiadiazoles and anticancer activity.
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 08 Jun 2011 06:31
Last Modified: 08 Jun 2011 06:31
URI: http://eprints.manipal.edu/id/eprint/175

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