In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells

Sunil, Dhanya and Isloor, Arun M and Shetty, Prakash and Nayak, Pawan G and Pai, K.S.R (2013) In vivo anticancer and histopathology studies of Schiff bases on Ehrlich ascitic carcinoma cells. Arabian Journal of Chemistry, 6. pp. 25-33. ISSN 1878-5352

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Abstract

Three Schiff bases in two different concentrations were evaluated for their anti-tumor activity against Ehrlich ascites carcinoma (EAC) bearing Swiss albino mice. The in vivo anti-tumor potency of Schiff bases was assessed by measuring the increase in mean survival time of the drug treated over untreated control mice and treated standard (cisplatin) mice. Their toxicity was assessed in vivo in normal, standard, and EAC-bearing mice by measuring the drug-induced changes in biochemical as well as hematological parameters. The histopathology studies to assess the toxicity of these compounds on vital organs also have been studied. Among the three Schiff bases studied, 4-({[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene}amino)-5-[(2-methylphenoxy)methyl]-1,2,4- triazole-3-thiol (SB-3) at an optimal dose of 100 mg/kg body weight was found to enhance the mean survival time of infected mice. Deviated hematological parameters and mean survival time in tumor bearing mice were found to be significantly restored towards normal after treatment with SB-3

Item Type: Article
Uncontrolled Keywords: Schiff base; EAC; Hematology; Biochemical; Histopathology
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 28 Jun 2011 06:32
Last Modified: 20 Feb 2013 04:50
URI: http://eprints.manipal.edu/id/eprint/377

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