Comparative Study Of One-Day Perioperative Antibiotic Prophylaxis Versus Seven-Day Postoperative Antibiotic Coverage In Elective Surgical Cases

Thejeswi, Poorna Chandra and Shenoy, Diwakar and *, Leo F Tauro and *, Shankar HS Ram (2012) Comparative Study Of One-Day Perioperative Antibiotic Prophylaxis Versus Seven-Day Postoperative Antibiotic Coverage In Elective Surgical Cases. The Internet Journal of Surgery, 28 (2).

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Abstract

Aim: Postoperative wound infection remains the most common complication of surgery; routine use of antibiotics for a prolonged period after clean surgery is not justifiable, so an attempt is made to assess the efficacy and advantages of one-day perioperative antibiotic administration versus a seven-day postoperative antibiotic regimen in preventing wound infection and to study the bacteriology of wound infection.Objectives: 1) To assess the efficacy and advantages of oneday perioperative antibiotic administration versus a seven-day postoperative antibiotic regimen in prevention of wound infection after elective surgery. 2) To study the bacteriology of postoperative wound infection. 3) To study the cost efficacy of both regimens.Materials and Methods: A total of 300 patients were included in the study. The patients were divided randomly into 2 groups, each containing 150 patients. Group I patients received 2 doses of antibiotics: one dose half an hour prior to surgery and the next dose 12 hours after the first dose. Group II patients were given antibiotics postoperatively for 7 days. This study was conducted using cephalosporin antibiotics. The wound was inspected on the 3rd, 5th and 7th postoperative day for local erythema, raise in temperature, induration and discharge. Results: The rate of wound infection in group I was 2.66% and in group II it was 4.66%. There was no statistical significance: p-value 0.357 and c2=0.849. Staph. aureus was the most common organism causing wound infection in 45.5%.Conclusion: One-day perioperative antibiotics are sufficient and cost effective. Postoperative antibiotics are unnecessary.

Item Type: Article
Uncontrolled Keywords: Perioperative, postoperative, antibiotic, wound infection.
Subjects: Medicine > KMC Mangalore > Surgery
Depositing User: KMCMLR User
Date Deposited: 09 May 2012 10:43
Last Modified: 09 May 2012 10:43
URI: http://eprints.manipal.edu/id/eprint/76390

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