Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles

Ubaradka, S R and Isloor, Arun M and Shetty, Prakash and Shetty, Prashanth and Isloor, Nishitha (2013) Synthesis, characterization and their anticonvulsant, anti-inflammatory studies of some novel chromeno oxadiazoles. Medicinal Chemistry Research , 22. pp. 1497-1503. ISSN 1554-8120

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Abstract

In this study, a series of new 1,2,4-oxadiazole derivatives containing 3,4-dihydro-2H-chromen-2-amine moiety were synthesized by efficient microwave reaction of 2-amino-N0-hydroxychroman-3-carboxamidine and suitable aldehyde. Structures of all the synthesized compounds were confirmed by spectral studies and C, H, N analyses. Newly synthesized compounds were screened for their anticonvulsant and anti-inflammatory properties. Few of the compounds exhibited excellent anticonvulsant activity as compared to the standard drug Diazepam. Also compounds have exhibited moderate anti-inflammatory activity as compared to the standard drug Diclofenac sodium.

Item Type: Article
Additional Information: Springer Science+Business Media, LLC 2012
Uncontrolled Keywords: Chromeno oxadiazole; Anticonvulsant activity � Anti-inflammatory activity
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 16 Feb 2013 04:14
Last Modified: 16 Feb 2013 04:14
URI: http://eprints.manipal.edu/id/eprint/78443

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